Over the past year, the BHBD programme has been mainly focusing on the scientific research and international collaboration in response to the COVID-19 pandemic. Significant progress has been achieved on the construction of the 2019 Novel Coronavirus Resource (2019nCoVR), tracing of virus origins, dynamic monitoring of virus genomes, virus variation analysis and literature mining. Since its online release on January 22, 2020, the 2019nCoVR has provided data service for over 186,000 visitors from 175 countries/regions, with accumulated data download exceeding 200 million pieces. 

The total omics data archived in the National Genomics Data Center, China National Center for Bioinformation (the data platform of this programme) has exceeded 6.1 PB, with an average of 1 TB of data uploaded/downloaded per day. An international research project between China and Pakistan on the SARS-CoV-2 genome sequencing and analysis has been conducted on 150 SARS-CoV-2 samples from Pakistan. We organized three online international meetings in 2020 for biodiversity and health big data sharing, and participated a number of meetings to promote the programme. As of December 2020, 27 organization members from 12 countries have joined the BHBD Alliance. 


Meetings/conferences/ workshops organized by the programme:

1. The 2020 Annual Meeting of BHBD Alliance. July 21, 2020, online, 20 participants. Countries involved: Brazil, China, France, Pakistan, Russia, Saudi Arabia, Thailand. 

2. The 5th Big Data Forum for Life and Health Sciences, October 15, 2020, online, 500 participants. Countries involved: China, Sweden, UK, USA.? 

3. Webinar on COVID-19 Resources. December 4, 2020, online, 30 participants. Countries involved: Brazil, China, Iran, Malaysia, Pakistan, Russia, Thailand.?? 


Presentations of the programme at meetings/conferences/workshops:

  • EU-China Webinar on data sharing, May 29, 2020, online. 
  • The 2020 Annual Meeting of INSDC, June 5, 2020, online. 
  • WeMissIPRES 2020, September 24, 2020, online. 
  • The 9th National Conference on Bioinformatics and Systems Biology of China, September 27, 2020, Shanghai, China. 
  • ANSO Scientific Webinar on Combating COVID-19, October 9, 2020, online. 
  • Asia Pacific Chromosome Colloquium 7, November 27, 2020, online.  
  • ANSO Workshop for Belt and Road Innovation Development, December 5, 2020, Beijing, China. 
  • American Society for Microbiology NGS Meeting, December 7-11, 2020, online. 
  • GPB Frontier Symposium 2020, December 19, 2020, online.  
  • The 5th Annual Meeting of Chinese Scholars in NIH & The Forum on Major Disease Precision Treatment, December 26, 2020, Shenzhen, China. 


Articles published (title, authors, journal, DOI): 

  • Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. CNCB-NGDC Members and Partners. Nucleic Acids Res. DOI: 10.1093/nar/gkaa1022. 
  • The global landscape of SARS-CoV-2 genomes, variants, and haplotypes in 2019nCoVR. Song, S. et al. Genomics Proteomics Bioinformatics. DOI: 10.1016/j.gpb.2020.09.001. 
  • Evolutionary and structural analysis of SARS-CoV-2 specific evasion of host immunity. Hussain I. et al. Genes & Immunity. DOI: 10.1038/s41435-020-00120-6. 
  • Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders. Nawaz, M. S. et al. BMC Evol Biol. DOI: 10.1186/s12862-020-01684-7. 
  • Comparative Plastomics of Ashwagandha (Withania, Solanaceae) and Identification of Mutational Hotspots for Barcoding Medicinal Plants. Mehmood F. et al. Plants. DOI: 10.3390/plants9060752. 

Development of partnership: 

As of December 2020, 27 organization members from 12 countries have joined the BHBD Alliance. 


Other outcome

An international research project between China and Pakistan on the SARS-CoV-2 genome sequencing and analysis has been conducted on 150 SARS-CoV-2 samples from Pakistan. 

Nationalities and names of people participating in the programme: 

  • China: Yongbiao Xue, Zhang Zhang, Wenming Zhao, Jingfa Xiao, Lan Li, Xin Zhang 
  • Brazil: Ana Tereza Ribeiro de Vasconcelos 
  • France: Sofia Kossida 
  • Japan: Takashi Gojobori 
  • Pakistan: Amir Ali Abbasi 
  • Russia: Vsevolod Makeev 
  • Thailand: Suchinda Malaivijitnond  
  • USA: Yiming Bao 


Action plan for 2021 

  • Events, key milestones in the implementation of the project, expected results… 
  • Network expansion for new members of BHBD Alliance. 
  • Database construction for omics big data deposition, integration and translation. 
  • Organize the 2021 Annual Meeting of BHBD Alliance, July 2021. 
  • Organize the 6th Big Data Forum for Life and Health Sciences, October 2021. 
  • Promote the programme in various meetings/conferences/workshops. 
  • Advance international scientific research and publish 1~2 papers in SCI journals.